Blood/Blood Cells and Cellular Components ›› Red Blood Cells ›› Abnormal

Macrocytic RBC: MCV >100*

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Microscopic Features:
  • Slightly larger than a normal mature RBC which correlates to the MCV of >100 fL
  • Round to oval in shape (lacks a nucleus similar to the normal RBC)
  • Cytoplasm is pink-orange in color wth a central pallor (similar to a normal RBC)
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: Rare to None
May Resemble: Differential Diagnoses:

Vitamin B12 or folate deficiency
Chemotherapy (e.g. Methotrexate)
Liver disease
Thyroid disease

Classic Immunophenotype:
  • N/A
Cartoon Image:

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  • Must rule out B12 or Folate deficiency

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD