Blood/Blood Cells and Cellular Components ›› Red Blood Cells ›› Abnormal

Stomatocyte*


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› Microscopic Features:

• About the same size as a normal RBC
• Slit-like or mouth-like central pallor (Hence the term stoma)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare to None
• BM: Rare to None
• LN: Rare to None

› May Resemble:

• Normal Mature RBC [Compare]
• Macrocytic RBC [Compare]

› Differential Diagnoses:

Increased in: Hereditary stomatocytosis Liver disease Tangier disease Rh null disease Artifact

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• Similar to Hereditary Spherocytosis, Hereditary Stomatocytosis is also due to an underlying RBC membrane defect