Increased in: Thalassemia Hemoglobinopathies (C, SC, or E disease) Post-splenectomy Liver disease Artifact of slow drying of blood smear Iron deficiency anemia (sometimes)
› Classic Immunophenotype:
N/A
› Cartoon Image:
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› Misc:
Increased surface membrane to volume ratio gives rise to a central darker hemoglobinized region within the area of central pallor