Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Nucleated RBC with Parvovirus Infection*

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Microscopic Features:
  • Very large erythroid precursor with intensely blue and often vacuolated cytoplasm
  • Nucleus with viral changes: Pale to moderate purple inclusion-like nucleoli or inclusions
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

Malignancy (e.g. MDS)
CMV infection (typically involves WBCs)

Classic Immunophenotype:
  • N/A
Cartoon Image:

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  • A background of erythroid hypoplasia may also be present. Parvo B19 may be associated with Aplastic anemia and pure red cell aplasia

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD