Blood/Blood Cells and Cellular Components ›› Red Blood Cells ›› Abnormal

Basophilic Stippling*

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Microscopic Features:
  • Very small (dot-like) Blue or blue-gray granules distributed throughout the cytoplasm of RBCs
  • Composed of ribosomes
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

Lead poisoning
Sickle cell anemia

Classic Immunophenotype:
  • N/A
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  • Note: Basophilic stippling is ribosomal inclusions in RBCs, while Pappenheimer bodies are iron deposits, Heinz bodies are precipitated hemoglobin seen with special stain (He for Heinz and He for Hemoglobin), and Howell Jolly bodies are DNA remnants

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD