Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Erythroid Leukemia (AML M6)*

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Additional Image 1

Microscopic Features:
  • Marked increase in immature erythroid precursors
  • Background of increased erythroid precursors with dysplastic features is also common (Note: the multinucleated erythroid precursor on the left side of the image)
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

AML (other subtypes)

Classic Immunophenotype:
  • Pure Eythroid-type:
  • CD34-
  • HLADR-
  • CD117+/-
  • CD235a (Glycophorin A)+
  • Hemoglobin A +
  • MPO-
  • ---------------------------
  • Erythroid/Myeloid type
  • *Erythroblasts are usually:
  • CD235a (Glycophorin A)+
  • Hemoglobin A +
  • CD71 dim or -
  • MPO-
  • *Myeloblasts may be:
  • CD34+
  • CD117+
  • MPO-/+
Cartoon Image:

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  • 2 types: In "Pure Erythroid"-type (less common) the bone marrow is comprised of 80% or more erythroid precursors while the "Erythroid/Myeloid" type has 50% or more erythroid precursors in the bone marrow with 20% or more myeloblasts (% myeloblasts is calculated in the non-erythroid cells) Note: As opposed to other AMLs which usually have 20% or more myeloblasts (as calculated from the total number of nucleated cells), in the Erythroid/Myeloid type of AML-M6: %myeloblasts are calculated after subtracting the background erythroid precursors.

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD