Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Normal

Band Neutrophil*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Kidney bean-shaped Nucleus with nucleus indentation (more than 1/2 the diameter indented) and mature chromatin (clumped)
• Nucleoli are absent
• More cytoplasm with only secondary granules
• Secondary (specific) granules are neutrophilic (lilac)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare scattered
• BM: Scattered
• LN: None

› May Resemble:

• Segmented Neutrophil [Compare]
• Metamyelocyte [Compare]
• Myelocyte [Compare]
• Promyelocyte [Compare]
• Monocyte [Compare]

› Differential Diagnoses:

Increased in: Infections (especially bacterial infections) Myeloproliferative disorders (e.g. CML) Leukemoid reaction Drug-induced

› Classic Immunophenotype:

• CD34-
• CD117-
• HLA-DR-
• CD10+
• CD13+
• CD33+
• CD15+
• CD11b+
• CD16+
• MPO+

› Cartoon Image:


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for direct comparison
› Misc:

• In normal blood the band forms are almost all neutrophilic and eosinophilic and basophilic band forms are confined to the bone marrow when present