Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Normal
Band Neutrophil*
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› Microscopic Features:- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Kidney bean-shaped Nucleus with nucleus indentation (more than 1/2 the diameter indented) and mature chromatin (clumped)
- Nucleoli are absent
- More cytoplasm with only secondary granules
- Secondary (specific) granules are neutrophilic (lilac)
› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:- PB: Rare scattered
- BM: Scattered
- LN: None
› May Resemble:
› Differential Diagnoses:
Increased in: Infections (especially bacterial infections) Myeloproliferative disorders (e.g. CML) Leukemoid reaction Drug-induced |
› Classic Immunophenotype:- CD34-
- CD117-
- HLA-DR-
- CD10+
- CD13+
- CD33+
- CD15+
- CD11b+
- CD16+
- MPO+
› Cartoon Image:
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for direct comparison › Misc:- In normal blood the band forms are almost all neutrophilic and eosinophilic and basophilic band forms are confined to the bone marrow when present
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