Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

May Hegglin Anomaly*

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Microscopic Features:
  • Characterized by neutrophils with prominent Dohle-like bodies and background Giant platelets
  • The Dohle-like bodies are half the diameter of an RBC with light blue crescent shaped appearance
  • Besides the neutrophils, other granulocytes, monocytes, and lymphocytes may also be involved
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

May Hegglin Anomaly
Infection associated

Classic Immunophenotype:
  • CD45+
  • High SCC
  • CD10+
  • CD11b+
  • CD13+
  • CD16+
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  • Associated with mutation in MYH-9 (Myosin Heavy Chain gene) May Hegglin: Neutrophil with Dohle-like body & background Giant Platelets

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD