Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

May Hegglin Anomaly*


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› Microscopic Features:

• Characterized by neutrophils with prominent Dohle-like bodies and background Giant platelets
• The Dohle-like bodies are half the diameter of an RBC with light blue crescent shaped appearance
• Besides the neutrophils, other granulocytes, monocytes, and lymphocytes may also be involved

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Chediak-Higashi inclusions [Compare]
• Neutrophil with toxic granules [Compare]
• Mature Segmented Neutrophil [Compare]

› Differential Diagnoses:

May Hegglin Anomaly Infection associated

› Classic Immunophenotype:

• CD45+
• High SCC
• CD10+
• CD11b+
• CD13+
• CD16+

› Cartoon Image:


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› Misc:

• Associated with mutation in MYH-9 (Myosin Heavy Chain gene) May Hegglin: Neutrophil with Dohle-like body & background Giant Platelets