Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Normal

Lymphocyte-Normal*


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› Microscopic Features:

• Slightly (1.5x) larger than a mature RBC
• High nuclear to cytoplasmic ratio but with
• Round mature Nucleus (clumped chromatin)
• Nucleoli are absent
• Cytoplasm is scant, light blue and lacks granules

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Many (second most common WBC component of blood)
• BM: Scattered
• LN: B-cells mainly in follicular areas and T-cells mainly in Interfollicular areas

› May Resemble:

• Orthochromic normoblast [Compare]
• Plasma cell (mature) [Compare]
• Reactive lymphocyte [Compare]
• Monocyte [Compare]

› Differential Diagnoses:

Increased number of normal (non-neoplastic) lymphocytes may be associated with: Infection (Viral, fungal, and some bacterial) Autoimmune disorders

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• Normal lymphocytes are the second most common WBCs in the blood (after neutrophils)