Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Abnormal

Lymphocyte-Abnormal*


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› Microscopic Features:

• Range in size from slightly (1.5x) larger than a mature RBC to 2-4x larger than a RBC
• High nuclear to cytoplasmic ratio but with
• Round mature Nucleus (clumped chromatin)
• Nucleoli are absent in most
• Cytoplasm is scant, light blue and lacks granules

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Orthochromic normoblast [Compare]
• Plasma cell (mature) [Compare]
• Reactive lymphocyte [Compare]
• Monocyte [Compare]

› Differential Diagnoses:

If increased in blood, Lymph node or bone marrow: Infection Neoplastic (mature B or T-cell lymphoma or leukemia)

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• It is not possible to distinguish T-cells and B-cells based on morphology alone.