Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Abnormal

Sezary Cell*


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› Microscopic Features:

• Small to intermediate sized lymphocytes
• Irregular nuclear membrane (cerebriform nucleus: looks like "Brain")
• Nucleoli are usually absent
• Scant amount of light blue cytoplasm

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Lymphocyte (mature) [Compare]
• Polychromatophilic RBC [Compare]

› Differential Diagnoses:

Sezary Syndrome Other T-cell lymphoproliferative disorders with blood involvement

› Classic Immunophenotype:

• CD3+
• CD4+
• CD8-
• CD7-

› Cartoon Image:


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› Misc:

• Sezary syndrome refers to a triad of Erythroderma (likely with skin involvement by the underlying T-cell lymphoma), Lymphadenopathy, and circulating abnormal neoplastic T-cell in the blood