Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Abnormal

Sezary Cell*

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Microscopic Features:
  • Small to intermediate sized lymphocytes
  • Irregular nuclear membrane (cerebriform nucleus: looks like "Brain")
  • Nucleoli are usually absent
  • Scant amount of light blue cytoplasm
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

Sezary Syndrome
Other T-cell lymphoproliferative disorders with blood involvement

Classic Immunophenotype:
  • CD3+
  • CD4+
  • CD8-
  • CD7-
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  • Sezary syndrome refers to a triad of Erythroderma (likely with skin involvement by the underlying T-cell lymphoma), Lymphadenopathy, and circulating abnormal neoplastic T-cell in the blood

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD