Blood/Blood Cells and Cellular Components ›› Platelets ›› Normal
Platelets*
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 › Microscopic Features:- Most are 1/5 to 1/3 the size of a normal RBC
- They are typically round with a blue-bray cytoplasm
- Cytoplasm with purple/blue granules
 › Normal % blood-PB, marrow-BM, lymphoid tissue-LN:- PB: Many
- BM: Scattered
- LN: None
 › May Resemble:
 › Differential Diagnoses:
Increased in: Iron deficiency Anemia Acute or chronic inflammation Myeloproliferative Neoplasm (e.g. Essential Thrombocythemia, etc.) Drug reaction Exercise
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Decreased in: Microangiopathic Hemolytic Anemias (e.g. DIC, TTP, and HUS) Malignancy with Marrow infiltration Drug induced Infection (e.g. sepsis leading to DIC) Autoimmune (e.g. ITP) Nutritional deficiencies Splenic sequestration Hereditary |
 › Classic Immunophenotype:
 › Cartoon Image:
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 for direct comparison › Misc:- Platelets are the smallest cellular fragments noted on a peripheral blood smear
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