Blood/Blood Cells and Cellular Components ›› Platelets ›› Abnormal

Agranular Platelets*

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Microscopic Features:
  • Smaller than a normal RBC (usually much smaller, similar to normal platelets)
  • Lacks the darker staining platelet granules
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: None
May Resemble: Differential Diagnoses:

Increased numbers may be see in:
Myeloid neoplasms (e.g. MDS, Acute leukemia or
Myeloproliferative Neoplasms)
Gray platelet syndrome (Alpha storage pool disease)

Classic Immunophenotype:
  • CD41+
  • CD61+
Cartoon Image:

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  • Lack of platelet granules may be indicative of an underlying abnormality of the platelets such as but not limited to the inability of producing certain platelet granules.

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD