Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Normal


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Microscopic Features:
  • 2-3x larger than a mature RBC
  • Low nuclear to cytoplasmic (N/C) ratio (cytoplasm is relatively increased)
  • Kidney bean-shaped Nucleus with nucleus indentation (Greater than 1/2 the diameter of the nucleus is indented) and mature chromatin (clumped)
  • Nucleoli are absent
  • More cytoplasm with only secondary granules
  • Secondary (specific) granules of neutrophilic (lilac), eosinophilic (red-orange), or basophilic (blue) color are present based on precursor type
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare scattered (~1-5%)
  • BM: Scattered (~10-15%)
  • LN: Rare to None
May Resemble: Differential Diagnoses:

Increased in:
Infections (especially bacterial)
Myeloproliferative disorders (e.g. CML)
Leukemoid reaction due to stress, etc.
Post-GCSF therapy

Classic Immunophenotype:
  • CD34-
  • CD117-
  • HLA-DR-
  • CD13+
  • CD33+
  • CD15+
  • CD11b+
  • CD16+
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  • When Bandemia (increased bands in blood) is noted, an underlying infection (specially bacterial) needs to be ruled out

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD