Increased in: Polycythemia Vera Post-erythropoietin therapy Reactive Erythroid Hyperplasia
› Classic Immunophenotype:
CD45 dim to -
CD235a (Glycophorin A) very dim+
› Cartoon Image:
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In normal marrow they comprise 2-3% of the total nucleated cells which is approximately 5-8% of the nucleated red blood cells precursors.Note: As Erythroid precursors mature, the color of their cytoplasm changes from blue to gray to red-orange (this is due to the increase in the number of hemoglobin molecules within the red cells as they mature). Additionally, the nucleus of the red blood cell will become more dense as it matures, eventually excreting from the cell forming the mature RBC.