Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Histoplasmosis in Histiocytes*


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› Microscopic Features:

• Small round fungal forms seen within the cytoplasm of mature monocytes and histiocytes

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Leishmania in Histiocytes [Compare]
• Cellular debris in Histiocytes
• Bacteria in Histiocytes

› Differential Diagnoses:

Histoplasmosis Leishmaniasis Cellular debris within histiocytes Bacterial infection

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• Histoplasma fungal forms lack kinetoplasts (small dark blue rod shaped structures within the organism) which are present in leishmania