Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal


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Microscopic Features:
  • 3-6x larger than a mature RBC
  • Lower nuclear to cytoplasmic ratio because of increased cytoplasm
  • Many are hypolobated (1-2 lobes) with a mature (clumped chromatin) nucleus
  • Nucleoli are absent
  • Cytoplasm is abundant and light blue and usually lacks granules
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble: Differential Diagnoses:

Usually sssociated with:
Post Chemotherapy

Classic Immunophenotype:
  • CD41+
  • CD42+
  • CD61+
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  • May be associated with a myelodysplastic syndrome (MDS)

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD