Increased in: Reactive Erythroid hyperplasia Post-erythropoietin therapy Polycythemia Vera
› Classic Immunophenotype:
CD45-
CD117-
CD235a (Glycophorin A) +
CD71+
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› Misc:
Normally confined in bone marrow where they comprise many of the nucleated red blood cell precursors.Note: As Erythroid precursors mature, the color of their cytoplasm changes from blue to gray to red-orange (this is due to the increase in number of hemoglobin molecules within the red cells as they mature). Additionally, the nucleus of the red blood cell will become more dense as it matures, eventually excreting from the cell forming the mature RBC.