Increased in: Newborns In response to certain anemias (e.g. hemolytic anemia) In response to acute blood loss In response to a recovering marrow (post therapy) Reactive Erythroid hyperplasia Post-erythropoietin therapy Polycythemia Vera
› Classic Immunophenotype:
CD235a (Glycophorin A) +
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They lack a nucleus. Scattered cells can also be seen in the blood. The grayish color of the cytoplasm is due to its increase number of RNA moelcules since these cells are still less mature than the fully mature RBC
Note: As Erythroid precursors mature, the color of their cytoplasm changes from blue to gray to red-orange (this is due to the increase in the number of hemoglobin molecules within the red cells).