Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Normal

Normal mature RBC*

Click Here for Full Size

Microscopic Features:
  • Size 6-8 um, slightly smaller than a mature lymphocyte
  • Lacks a nucleus
  • Cytoplasm is pink-orange in color with a central pallor
  • Central pallor is 1/3 the diameter
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Many
  • BM: Many
  • LN: Some
May Resemble: Differential Diagnoses:

Increased in:
Reactive Erythroid hyperplasia
Post-erythropoietin therapy
Polycythemia Vera

Classic Immunophenotype:
  • CD45-
  • CD117-
  • CD235a (Glycophorin A) +
  • CD71-
Cartoon Image:

Click and drag
for direct comparison

  • Normal mature RBCs are normocytic (MCV 80-100) and normochromic (1/3 central pallor).Its main function is to carry oxygen through its hemoglobin molecules. Note: As Erythroid precursors mature, the color of their cytoplasm changes from blue to gray to red-orange (this is due to the increase in the number of hemoglobin molecules within the red cells as they mature). Additionally, the nucleus of the red blood cell will become more dense as it matures, eventually excreting from the cell forming the mature RBC.

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD