Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

Mantle Cell Lymphoma*


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› Microscopic Features:

• The lymph node is usually effaced (closed subcapsular sinus and loss of follicle architecture)
• The lymphoid tissue is replaced by usually a diffuse lymphoid proliferation of small to intermediate-sized notched lymphocytes (the abnormal lymphocytes have irregular nuclear membranes)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: N/A
• BM: N/A
• LN: N/A

› May Resemble:

• Non-neoplastic reactive Lymph node [Compare]
• Small Lymphocytic Lymphoma [Compare]
• Follicular Lymphoma (specially the nodular variant of Mantle Cell Lymphoma) [Compare]

› Differential Diagnoses:

Non-neoplastic reactive lymph node Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue) Follicular lymphoma (specially the nodular variant of Mantle cell lymphoma) Burkitt Lymphoma Diffuse Large B-cell Lymphoma

› Classic Immunophenotype:

• CD19+
• CD20+
• CD5+
• CD23-
• BCL1+ (CyclinD1+)

› Cartoon Image:


› Misc:

• BCL1+ (Cyclin D1+). Associated with t(11;14) CyclinD1:IgH genes Note: Lymphomatoid Polyposis is "Mantle cell lymphoma" involving the colon and may resemble a polyp Note: As opposed to CLL which is CD5+/CD23+, Mantle cell lymphoma is typically CD5+/CD23-