Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

Burkitt Lymphoma*


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› Microscopic Features:

• "Starry Sky" pattern due to many background apoptotic cells
• The lymph node is usually effaced (closed subcapsular sinus and loss of follicle architecture)
• The normal lymphoid tissue is replaced by a diffuse lymphoid proliferation of intermediate sized lymphocytes with a very high mitotic rate

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: N/A
• BM: N/A
• LN: N/A

› May Resemble:

• Diffuse Large B-cell Lymphoma [Compare]
• Small Lymphocytic Lymphoma [Compare]
• Mantle Cell Lymphoma [Compare]
• Non-neoplastic reactive Lymph node [Compare]

› Differential Diagnoses:

Non-neoplastic reactive Lymph node Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue) Mantle Cell Lymphoma Diffuse Large B-cell Lymphoma Follicular Lymphoma

› Classic Immunophenotype:

• CD19+
• CD20+
• CD10+
• BCL2-
• CD5-
• Ki67 proliferation index is nearly 100%

› Cartoon Image:


› Misc:

• Associated with t(8;14) c-MYC;IgH genes Less commonly associated with other translocations including the light chains (kappa or lambda): t(2:8) or t(8;22)