Secondary Lymphoid Tissues ›› Spleen ›› Normal

Normal Spleen*

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Additional Image 1 Additional Image 2

Microscopic Features:
  • Spleen is divided into 2 main zones: Red pulp and white pulp
  • The white pulp contains the lymphoid cells and appears as small blue/purple aggregates of lymphoid tissue
  • The red pulp contains the sinusoids along with scattered hematopoietic cells and appears red in the image above
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: N/A
  • BM: N/A
  • LN: N/A
May Resemble: Differential Diagnoses:

Reactive lymphoid hyperplasia
Splenic Marginal Zone Lymphoma
Hairy Cell Leukemia
Follicular Lymphoma

Classic Immunophenotype:
  • "T"-cells have the "Tiny" CDs: CD2, CD3, CD4, CD5, CD7, CD8
  • "B"-cells have the "Bigger" CDs: CD19, CD20, CD22
  • In Splenic Marginal Zone Lymphoma, the neoplastic cells involve the white pulp area of the Spleen (as opposed to Hairy Cell Leukemia which involves the red pulp area)

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD