Secondary Lymphoid Tissues ›› Spleen ›› Abnormal

Splenic Marginal Zone Lymphoma*


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› Microscopic Features:

• Peripheral blood smear shows lymphocytes with Villous cytoplasmic projections (may resemble hair-like projections of Hairy Cell Leukemia)
• ymphocytes with villous-like projections are intermediate in size
• Lacks a prominent nucleolus

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Hairy Cell Leukemia [Compare]
• Reactive lymphocyte [Compare]
• CLL [Compare]

› Differential Diagnoses:

Hairy Cell Leukemia Reactive Lymphocytosis CLL

› Classic Immunophenotype:

• CD19+
• CD20+
• CD5-
• CD10-
• CD11c-
• CD103-
• CD25-
• Annexin1-

› Cartoon Image:


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› Misc:

• The neoplastic cells typically involve the white pulp area of the spleen (as opposed to Hairy Cell Leukemia which involves the red pulp).