Blood/Blood Cells and Cellular Components ›› Red Blood Cells ›› Abnormal

Bite Cell RBC*






Microscopic Features:
  • Usually slightly smaller than a normal RBC
  • The RBC has a "bitten" appearance (like a bitten apple)
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: Rare to None
May Resemble:
  • Schistocyte (Helmet cell type)
  • Normal Mature RBC
Differential Diagnoses:

Increased in:
G6PD deficiency
Unstable hemoglobin disorders
Oxidative drug-effect

Classic Immunophenotype:
  • N/A
Cartoon Image:



Misc:
  • Commonly associated with disorders in which precipitated oxidized hemoglobin on RBC membrane (e.g. Heiz bodies in RBCs of G6PD patients) is removed as they pass through the spleen ultimately forming a bite-shape RBC appearance