Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Histoplasmosis in Histiocytes*






Microscopic Features:
  • Small round fungal forms seen within the cytoplasm of mature monocytes and histiocytes
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble:
  • Leishmania in Histiocytes
  • Cellular debris in Histiocytes
  • Bacteria in Histiocytes
Differential Diagnoses:

Histoplasmosis
Leishmaniasis
Cellular debris within histiocytes
Bacterial infection

Classic Immunophenotype:
  • N/A
Cartoon Image:



Misc:
  • Histoplasma fungal forms lack kinetoplasts (small dark blue rod shaped structures within the organism) which are present in leishmania