HematologyOutlines - Atlas
Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal
Plasmablast (Immature plasma cell)*
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![](/images/scope_icon.gif) › Microscopic Features:- 3-4x larger than a mature RBC
- Round eccentricly placed nucleus with less mature chromatin
- Moderate amount of basophilic (blue) cytoplasm with prominent perinuclear hof (clearing)
- Nucleoli are Prominent
![](/images/normal_icon.gif) › Normal % blood-PB, marrow-BM, lymphoid tissue-LN:- PB: None
- BM: None
- LN: None
![](/images/resemble_icon.gif) › May Resemble:- Polychromatophilic normoblast
- Plasma cell (mature)
- Myeloblast
- Osteoblast
- Pronormoblast
- Monoblast
- Reactive lymphocyte
![](/images/ddx_icon.gif) › Differential Diagnoses:
Plasma cell myeloma (plasmablastic form) Plasmablastic lymphoma Plasma cell leukemia |
![](/images/immuno_icon.gif) › Classic Immunophenotype:- CD138+
- CD38 bright+
- CD19-
- CD56- (more common)
- CD20-
- Cytoplasmic light chain restricted (kappa only or lambda only)
![](/images/cartoon_icon.gif) › Cartoon Image:
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![RBC](/images/rbc_clear.gif) for direct comparison![](/images/misc_icon.gif) › Misc:- Rarely found in normal bone marrow and rarely noted in non-neoplastic conditions
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