Sheets or clusters of large (>2.5x the size of a mature lymphocyte or equal or > than the size of a histiocyte) abnormal lymphocytes involving lymph node or other tissue
As the name suggests, the abnormal lymphocytes diffusely infiltrate the involved tissue (typically lacks a nodular/follicular pattern of growth)
› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
PB: N/A
BM: N/A
LN: N/A
› May Resemble:
Burkitt Lymphoma
Small Lymphocytic Lymphoma
Mantle Cell Lymphoma
Follicular Lymphoma
Non-neoplastic reactive Lymph node
Carcinoma
Melanoma
› Differential Diagnoses:
Mantle cell lymphoma (blastoid variant) Follicular lymphoma (high grade, e.g. 3B) Burkitt Lymphoma Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue) Mantle Cell Lymphoma Non-neoplastic reactive Lymph node Hodgkin Lymphoma
› Classic Immunophenotype:
CD19+
CD20+
CD10+ (Germinal center phenotype)
CD10-/BCL6-/MUM1+ (Non-Germinal Center phenotype)
› Misc:
Germinal center phenotype (CD10+) has better prognosis (usually responds better to R-CHOP chemotherapy treatment)
Many have variable morphology (some with prominent nucleoli, some with high mitotic rate, etc.) and many present as mass lesions
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› Microscopic Features:
› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
› May Resemble:
› Differential Diagnoses:
› Classic Immunophenotype:
› Misc: