HematologyOutlines - Atlas
Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

Mantle Cell Lymphoma*


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› Microscopic Features:
  • The lymph node is usually effaced (closed subcapsular sinus and loss of follicle architecture)
  • The lymphoid tissue is replaced by usually a diffuse lymphoid proliferation of small to intermediate-sized notched lymphocytes (the abnormal lymphocytes have irregular nuclear membranes)
› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: N/A
  • BM: N/A
  • LN: N/A
› May Resemble:
  • Non-neoplastic reactive Lymph node
  • Small Lymphocytic Lymphoma
  • Follicular Lymphoma (specially the nodular variant of Mantle Cell Lymphoma)
› Differential Diagnoses:

Non-neoplastic reactive lymph node
Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue)
Follicular lymphoma (specially the nodular variant of Mantle cell lymphoma)
Burkitt Lymphoma
Diffuse Large B-cell Lymphoma

› Classic Immunophenotype:
  • CD19+
  • CD20+
  • CD5+
  • CD23-
  • BCL1+ (CyclinD1+)
› Cartoon Image:



› Misc:
  • BCL1+ (Cyclin D1+). Associated with t(11;14) CyclinD1:IgH genes Note: Lymphomatoid Polyposis is "Mantle cell lymphoma" involving the colon and may resemble a polyp Note: As opposed to CLL which is CD5+/CD23+, Mantle cell lymphoma is typically CD5+/CD23-