Secondary Lymphoid Tissues ›› Spleen ›› Normal
Normal Spleen*
 › Microscopic Features:- Spleen is divided into 2 main zones: Red pulp and white pulp
- The white pulp contains the lymphoid cells and appears as small blue/purple aggregates of lymphoid tissue
- The red pulp contains the sinusoids along with scattered hematopoietic cells and appears red in the image above
 › Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
 › May Resemble:- Normal Lymph Node
- Normal Mucosa Associated Lymphoid Tissue (MALT)
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 › Differential Diagnoses:
Reactive lymphoid hyperplasia Infection Splenic Marginal Zone Lymphoma Hairy Cell Leukemia Follicular Lymphoma |
 › Classic Immunophenotype:- "T"-cells have the "Tiny" CDs: CD2, CD3, CD4, CD5, CD7, CD8
- "B"-cells have the "Bigger" CDs: CD19, CD20, CD22
 › Misc:- In Splenic Marginal Zone Lymphoma, the neoplastic cells involve the white pulp area of the Spleen (as opposed to Hairy Cell Leukemia which involves the red pulp area)
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