HematologyOutlines - Atlas
Secondary Lymphoid Tissues ›› Spleen ›› Abnormal

Splenic Marginal Zone Lymphoma*

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Microscopic Features:
  • Peripheral blood smear shows lymphocytes with Villous cytoplasmic projections (may resemble hair-like projections of Hairy Cell Leukemia)
  • ymphocytes with villous-like projections are intermediate in size
  • Lacks a prominent nucleolus
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble:
  • Hairy Cell Leukemia
  • Reactive lymphocyte
  • CLL
Differential Diagnoses:

Hairy Cell Leukemia
Reactive Lymphocytosis

Classic Immunophenotype:
  • CD19+
  • CD20+
  • CD5-
  • CD10-
  • CD11c-
  • CD103-
  • CD25-
  • Annexin1-
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  • The neoplastic cells typically involve the white pulp area of the spleen (as opposed to Hairy Cell Leukemia which involves the red pulp).