Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Normal

Band*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (cytoplasm is relatively increased)
• Kidney bean-shaped Nucleus with nucleus indentation (Greater than 1/2 the diameter of the nucleus is indented) and mature chromatin (clumped)
• Nucleoli are absent
• More cytoplasm with only secondary granules
• Secondary (specific) granules of neutrophilic (lilac), eosinophilic (red-orange), or basophilic (blue) color are present based on precursor type

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare scattered (~1-5%)
• BM: Scattered (~10-15%)
• LN: Rare to None

› May Resemble:

• Segmented Neutrophil
• Metamyelocyte
• Myelocyte
• Promyelocyte
• Monocyte

› Differential Diagnoses:

Increased in: Infections (especially bacterial) Myeloproliferative disorders (e.g. CML) Leukemoid reaction due to stress, etc. Post-GCSF therapy

› Classic Immunophenotype:

• CD34-
• CD117-
• HLA-DR-
• CD13+
• CD33+
• CD15+
• CD11b+
• CD16+

› Cartoon Image:


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› Misc:

• When Bandemia (increased bands in blood) is noted, an underlying infection (specially bacterial) needs to be ruled out