Textbook of Hematology

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Table of contents

SECTION 1: NON-NEOPLASTIC HEMATOLOGY

--Non-neoplastic disorders of red blood cells
----Normal Red Blood Cell (An Overview)
------Red blood cell function
------Red blood cell membrane major protein components
------Hemoglobin molecule
------Hemoglobin production
------Adult hemoglobin production and genes
------Hemoglobin oxygen saturation
------Oxyhemoglobin-deoxyhemoglobin
------Laboratory values associated with Red blood cells
--------Normal complete blood count (CBC) values
--------Hemoglobin (Hb) & Hemotocrit (Hct)
--------Red Blood Cell count (RBC)
--------Mean Corpuscular Volume or Mean Cell Volume (MCV)
--------Red cell Distribution Width (RDW)
--------Mean Corpuscular (or Cell) Hemoglobin Concentration (MCHC)
--------Mean Corpuscular (or Cell) Hemoglobin (MCH)
----Red Blood Cell Underproduction (Anemia)
------Microcytic anemia
--------Thalassemia
--------Iron deficiency anemia
--------Chronic disease associated anemia (sometimes)
--------Sideroblastic anemia (some such as lead poisoning)
------Normocytic anemia
--------Blood Loss associated anemia
--------Hemolytic anemia
----------Microangiopathic Hemolytic Anemias
------------Disseminated Intravascular Coagulation (DIC)
------------Thrombotic Thrombocytopenic Purpura (TTP)
------------Hemolytic Uremic Syndrome (HUS)
----------Cold Agglutinin disease
----------Paroxysmal Cold Hemoglobinuria (PCH)
----------Paroxysmal Nocturnal Hemoglobinuria (PNH)
----------Hemolytic transfusion reaction
----------Autoimmune Hemolytic Anemia
----------Sickle cell disease
----------Hereditary spherocytosis
----------Glucose-6-phosphate dehydrogenase (G6PD) deficiency
--------Anemia of Chronic disease and inflammation
--------Anemia of Renal disease
--------Aplastic anemia
--------Hypersplenism
--------Relative anemia due to increased plasma volume
----------Athletes
----------Pregnancy
------Macrocytic anemia
--------B12 deficiency associated anemia
--------Folate deficiency associated anemia
--------Drug associated (e.g. Methotrexate)
--------Liver disease associated
--------Thyroid disease associated
--------Myelodysplastic syndrome
--------Reticulocytosis-associated
----Hemoglobin-Associated disorders
------Common hemoglobinopathies
--------Sickle Cell (HbSS and HbS trait)
--------HbC
--------HbE
------Thalassemia
--------Alpha Thalassemia
--------Beta Thalassemia
----Enzyme or protein deficiency associated and Metabolic disorders
------G6PD deficiency
------Hereditary Spherocytosis
----Red Blood Cell Overproduction (Polycythemia)
------Polycythemia Vera (see neoplastic section: Myeloproliferative neoplasm)
------Hereditary
--------Familial Polycythemia
--------High oxygen affinity Hemoglobins
--------2,3-Bisphosphoglycerate deficiency
------Compensatory (Chronic lung disease, Sleep apnea, smoking, high altitude, or carboxyhomoglobenemia
------Excess Erythropoietin
--------Tumor associated (e.g. Renal Cell Carcinoma, VHL or HIF-alpha mutations, etc.)
--------Erythropoietin administration
------Spurious (e.g. relative decrease in plasma volume)
--------Drug-induced (e.g. post diuretics)
--------Dehydration
------Infections involving red blood cells
--------Malaria
--------Babesia
--------Trypanosoma
--------Microfilaria

--Non-neoplastic disorders of White Blood cells
----Neutrophil-associated disorders
----Monocyte-associated disorders
----Lymphocyte-associated disorders
------Non-neoplastic disorders of lymph nodes
--------Reactive lymphoid hyperplasia
--------Infectious lymphadenitis
------Lymphadenopathy associated with clinical diseases and syndromes
--------Rosai-Dorfman Disease
--------Kikuchi Fujimoto
--------Sarcoidosis
--------Systemic lupus erythematosus
--------Castleman's disease
------Drug-induced lymphadenopathy
--------Anti-seizure medications (e.g. phenytoin)

--Hemostasis Overview
----Normal hemostasis (Coagulation Cascade)
----Coagulation must know points
----Bleeding disorders
------Platelet or platelet-like disorders
------Coagulation disorders
----Thrombotic disorders


SECTION 2: NEOPLASTIC HEMATOLOGIC DISORDERS
(Under development)