Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Hypersegmented Neutrophil*


Click Here for Full Size

---

Additional Image 1

› Microscopic Features:

• 3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Nucleus is mature and has >5 lobes connected by thin chromatin filaments
• Nucleoli are absent
• More cytoplasm with only secondary granules
• Secondary (specific) granules are neutrophilic (lilac)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Mature Segmented Neutrophil [Compare]
• Pseudo-Pelger Huet Neutrophil [Compare]
• Band Neutrophil [Compare]
• Neutrophil with toxic granules [Compare]
• Metamyelocyte [Compare]
• Myelocyte [Compare]
• Promyelocyte [Compare]
• Monocyte [Compare]

› Differential Diagnoses:

Usually associated with: Vitamin B12 deficiency Folate deficiency

› Classic Immunophenotype:

• CD45+
• High SCC
• CD10+
• CD11b+
• CD13+
• CD16+

› Cartoon Image:


Click and drag

for direct comparison
› Misc:

• Usually associated with B12 or folate deficiency