Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Neutrophil with toxic granules*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Nucleus is mature and divided into 3 to 5 lobes connected by thin chromatin filaments
• Nucleoli are absent
• Darker (red/purple) granules are easily noted (similar to the primary granules noted in promyelocytes)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare to None
• BM: Rare to None
• LN: None

› May Resemble:

• Mature Segmented Neutrophil [Compare]
• HyperSegmented Neutrophil [Compare]
• Pseudo-Pelger Huet Neutrophil [Compare]
• Band Neutrophil [Compare]
• Large Granular Lymphocyte [Compare]
• Metamyelocyte [Compare]
• Myelocyte [Compare]
• Promyelocyte [Compare]
• Monocyte [Compare]

› Differential Diagnoses:

Usually associated with: Infection Inflammatory conditions

› Classic Immunophenotype:

• CD45+
• High SCC
• CD10+
• CD11b+
• CD13+
• CD16+

› Cartoon Image:


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› Misc:

• Usually associated with an underlying infection Neutrophils in infectious processes may also show vacuoles