Blood/Blood Cells and Cellular Components ›› Eosinophils and Basophils ›› Abnormal
Basophils (increased)*
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![](/images/scope_icon.gif) › Microscopic Features:- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Nucleus is mature and usually with 2-3 lobes connected by thin chromatin filament
- Nucleoli are absent
- More cytoplasm with only secondary granules
- Secondary (specific) granules are Basophilic (Blue-Violet) and obscure the underlying nucleus
![](/images/normal_icon.gif) › Normal % blood-PB, marrow-BM, lymphoid tissue-LN:- PB: Very Rare (5th most common WBC in blood, after neutrophils, lymphocytes, monocytes, and Eosinophils)
- BM: Rare scattered
- LN: None
![](/images/resemble_icon.gif) › May Resemble:
![](/images/ddx_icon.gif) › Differential Diagnoses:
Increased in: CML accelerated phase AML (rare variants) Infection (e.g. varicella) Hypersensitivity reactions (sometimes) |
![](/images/immuno_icon.gif) › Classic Immunophenotype:- CD45dim+
- Low SSC (Side light scatter)
- CD11b+
- CD13+
- CD16-
- CD15-
![](/images/cartoon_icon.gif) › Cartoon Image:
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![RBC](/images/rbc_clear.gif) for direct comparison![](/images/misc_icon.gif) › Misc:- Increased basophils may be associated with some myeloid neoplasms such as CML, or some infections or some hypersensitivity reactions
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