Increased numbers in bone marrow: Peripheral destruction of platelets (e.g. ITP) may lead to megakaryocytic hyperplasia in the bone marrow Myeloproliferative neoplasms Myelodysplastic Syndrome (specifically MDS with isolated 5q deletion)
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Megakaryocytes give rise to the platelets which circulate in blood.
Megakaryocytes are not present in the peripheral blood. Under normal circumstances they reside in the bone marrow and when the marrow is unable to produce (e.g. Primary Myelofibrosis), they may be seen in other organs such as the spleen as part of Extramedullary Hematopoeisis