HematologyOutlines - Atlas
Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Hypersegmented Neutrophil*

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Microscopic Features:
  • 3x larger than a mature RBC
  • Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
  • Nucleus is mature and has >5 lobes connected by thin chromatin filaments
  • Nucleoli are absent
  • More cytoplasm with only secondary granules
  • Secondary (specific) granules are neutrophilic (lilac)
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: None
  • BM: None
  • LN: None
May Resemble:
  • Mature Segmented Neutrophil
  • Pseudo-Pelger Huet Neutrophil
  • Band Neutrophil
  • Neutrophil with toxic granules
  • Metamyelocyte
  • Myelocyte
  • Promyelocyte
  • Monocyte
Differential Diagnoses:

Usually associated with:
Vitamin B12 deficiency
Folate deficiency

Classic Immunophenotype:
  • CD45+
  • High SCC
  • CD10+
  • CD11b+
  • CD13+
  • CD16+
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  • Usually associated with B12 or folate deficiency