HematologyOutlines - Atlas
Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Neutrophil with toxic granules*


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› Microscopic Features:
  • 2-3x larger than a mature RBC
  • Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
  • Nucleus is mature and divided into 3 to 5 lobes connected by thin chromatin filaments
  • Nucleoli are absent
  • Darker (red/purple) granules are easily noted (similar to the primary granules noted in promyelocytes)
› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: None
› May Resemble:
  • Mature Segmented Neutrophil
  • HyperSegmented Neutrophil
  • Pseudo-Pelger Huet Neutrophil
  • Band Neutrophil
  • Large Granular Lymphocyte
  • Metamyelocyte
  • Myelocyte
  • Promyelocyte
  • Monocyte
› Differential Diagnoses:

Usually associated with:
Infection
Inflammatory conditions

› Classic Immunophenotype:
  • CD45+
  • High SCC
  • CD10+
  • CD11b+
  • CD13+
  • CD16+
› Cartoon Image:



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RBC
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› Misc:
  • Usually associated with an underlying infection Neutrophils in infectious processes may also show vacuoles