Secondary Lymphoid Tissues ›› Lymph Node ›› Non-neoplastic

Lymphadenitis (Non-neoplastic)*






Microscopic Features:
  • Most do not show a completely effaced lymph node (as opposed to neoplastic processes such as lymphomas)
  • The morphology can be variable based on the underlying disease
  • Enlarged reactive secondary follicles are commonly seen
  • Increased number of Immunoblasts are also commonly noted
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: N/A
  • BM: N/A
  • LN: N/A
May Resemble:
  • Follicular Lymphoma
  • Non-neoplastic reactive Lymph node
  • Classical Hodgkin Lymphoma
Differential Diagnoses:

Drug-induced
Autoimmune-induced
Infection
Neoplastic (e.g. Follicular lymphoma)
Idiopathic (unknown cause)

Classic Immunophenotype:
  • "T"-cells have the "Tiny" CDs: CD2, CD3, CD4, CD5, CD7, CD8
  • "B"-cells have the "Bigger" CDs: CD19, CD20, CD22
Misc:
  • Non-neoplastic lymphadenitis can be due to infection, drugs, autoimmune, or ideopathic