Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Hypogranular or Agranular Neutrophil*

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Microscopic Features:
  • 2-3x larger than a mature RBC
  • Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
  • Nucleus is mature
  • Nucleoli are absent
  • Lack or diminished neutrophilic granules
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: None
May Resemble: Differential Diagnoses:

Increased in:
Myelodysplastic Syndrome
Staining artifact giving rise to pseudo-hypogranularity

Classic Immunophenotype:
  • CD45+
  • Lowered SCC
  • CD10+/-
  • CD11b+/-
  • CD13+/-
  • CD16+/-
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  • The low SCC noted in flow cytometry is due to the hypogranularity. The immunoprofile may be aberrant if it's dysplastic and associated with MDS

Content Editors/Website Administrators:
Hooman H. Rashidi, MD; John C. Nguyen, MD