Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal
Hypogranular or Agranular Neutrophil*
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![](/images/scope_icon.gif) › Microscopic Features:- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Nucleus is mature
- Nucleoli are absent
- Lack or diminished neutrophilic granules
![](/images/normal_icon.gif) › Normal % blood-PB, marrow-BM, lymphoid tissue-LN:- PB: Rare to None
- BM: Rare to None
- LN: None
![](/images/resemble_icon.gif) › May Resemble:
![](/images/ddx_icon.gif) › Differential Diagnoses:
Increased in: Myelodysplastic Syndrome Staining artifact giving rise to pseudo-hypogranularity |
![](/images/immuno_icon.gif) › Classic Immunophenotype:- CD45+
- Lowered SCC
- CD10+/-
- CD11b+/-
- CD13+/-
- CD16+/-
![](/images/cartoon_icon.gif) › Cartoon Image:
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![RBC](/images/rbc_clear.gif) for direct comparison![](/images/misc_icon.gif) › Misc:- The low SCC noted in flow cytometry is due to the hypogranularity.
The immunoprofile may be aberrant if it's dysplastic and associated with MDS
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