Blood/Blood Cells and Cellular Components ›› Eosinophils and Basophils ›› Normal

Eosinophil (Mature)*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Nucleus is mature and usually with 2 lobes connected by thin chromatin filament
• Nucleoli are absent
• More cytoplasm with only secondary granules
• Secondary (specific) granules are Eosinophilic (Red-Orange)

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Scattered (4th most common WBC in blood, after neutrophils, lymphocytes and monocytes)
• BM: Rare scattered
• LN: Rare to None

› May Resemble:

• Segmented Neutrophil [Compare]
• Pseudo-Pelger Huet Neutrophil [Compare]
• Band Neutrophil [Compare]
• Neutrophil with toxic granules [Compare]
• Promyelocyte [Compare]
• Basophil [Compare]

› Differential Diagnoses:

Increased in: Allergy-related (e.g. Asthma) Drug reactions Invasive parasitic infections Myeloproliferative neoplasms Hodgkin's and non-Hodgkin's lymphomas Autoimmune disorders (some)

› Classic Immunophenotype:

• CD45dim+
• High SSC (Side light scatter)
• CD13dim+
• CD16-
• CD15dim+

› Cartoon Image:


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› Misc:

• Increased amounts are commonly associated with: Drugs Allergy Infection (specially invasive multicellular parasites) Neoplasm (e.g. Myeloid neoplasms such as some AMLs or MPNs) Idiopathic