Blood/Blood Cells and Cellular Components ›› Eosinophils and Basophils ›› Abnormal

Dysplastic Eosinophil*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Nucleus is mature and usually with 2 lobes connected by thin chromatin filament (some have 1 lobe or more than 2 lobes)
• Nucleoli are absent
• More cytoplasm with Abnormal secondary granules (usually darker in color resembling basophilic granules)
• The granules are heterogenous and vacuoules may occasionally be noted as well

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Eosinophil [Compare]
• Basophil [Compare]
• Neutrophil (mature) [Compare]
• Pseudo-Pelger Huet Neutrophil [Compare]
• Band Neutrophil [Compare]

› Differential Diagnoses:

Associated with: Certain AMLs such as AML with Inv 16 or t(16;16) Certain Myeloproliferative neoplasms Certain Myelodysplastic Syndromes

› Classic Immunophenotype:

• CD45dim+
• High SSC (Side light scatter)
• CD13dim+
• CD16-
• CD15dim+
• (May have some immunophenotypic variability compared to normal eosinophils)

› Cartoon Image:


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› Misc:

• AML with inv16 or t(16;16) was also known as AML-M4Eo (which stood for an AML with monocytic differentiation and Abnormal Eosinophils)