Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Chediak Higashi Neutrophils*


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› Microscopic Features:

• Abnormal cytoplasmic inclusions invlolving the white blood cells (neutrophils, monocytes, eosinophils and lymphocytes)
• Variably sized large aggregates of purple/blue/red granules

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Eosinophil [Compare]
• Segmented Neutrophil [Compare]
• Band Neutrophil [Compare]
• Neutrophil with toxic granules [Compare]
• Basophil [Compare]

› Differential Diagnoses:

Chediak Higashi syndrome

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• Chediak Higashi syndrome: Caused from abnormal fusion of primary granules which results in a malfunctioning WBC with a diminished phagocytic capability. The syndrome is characterized by Pancytopenia, Neuropathy, Oculocuteneous Albinism, hepatosplenomegaly, lymphadenopathy, and recurrent infections.