Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Pseudo Pelger Huet Neutrophil*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic (N/C) ratio (more cytoplasm than nucleus)
• Nucleus is mature with 2 lobes connected by thin chromatin filament. Also the granules are neutrophilic (pink)
• Nucleoli are absent
• In some cases, hypergranulation, hypogranulation, or abnormal granules can be seen
• Pseudo Pelger-Huet neutrophils are a form of dysplastic neutrophils

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare to None
• BM: Rare to None
• LN: None

› May Resemble:

• Eosinophil [Compare]
• Segmented Neutrophil [Compare]
• Band Neutrophil [Compare]
• Neutrophil with toxic granules [Compare]
• Basophil [Compare]

› Differential Diagnoses:

Associated with: Myelodysplastic Syndrome (MDS) Pelger Huet Anamoly (if they are true Pelger Huet cells)

› Classic Immunophenotype:

• CD45+
• Lowered SCC
• CD10+/-
• CD11b+/-
• CD13+/-
• CD16+/-

› Cartoon Image:


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› Misc:

• Normal segmentation is 3-5 lobes while Hyposegmentation is <3 lobes and Hypersegmentation is >5 lobes The immunoprofile may be aberrant if it's dysplastic and associated with MDS