Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Pseudo Pelger Huet Neutrophil*






Microscopic Features:
  • 2-3x larger than a mature RBC
  • Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
  • Nucleus is mature with 2 lobes connected by thin chromatin filament. The granules are neutrophilic (pink)
  • Nucleoli are absent
  • In some cases, hypergranulation, hypogranulation, or abnormal granules can be seen
  • Pseudo Pelger-Huet neutrophils are a form of dysplastic neutrophils
Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
  • PB: Rare to None
  • BM: Rare to None
  • LN: None
May Resemble:
  • Eosinophil
  • Segmented Neutrophil
  • Band Neutrophil
  • Neutrophil with toxic granules
  • Basophil
Differential Diagnoses:

Associated with:
Myelodysplastic Syndrome (MDS)
Pelger Huet Anamoly (if they are true pelger huet cells)

Classic Immunophenotype:
  • CD45+
  • Lowered SCC
  • CD10+/-
  • CD11b+/-
  • CD13+/-
  • CD16+/-
Cartoon Image:



Misc:
  • Normal segmentation is 3-5 lobes while Hyposegmentation is <3 lobes and Hypersegmentation is >5 lobes The immunoprofile may be aberrant if it's dysplastic and associated with MDS