Hemoglobin C disease

A hemoglobinopathy that is due to a mutation that changes a hydrophilic residue (glutamate) on the hemoglobin's beta chain to another hydrophilic residue (Lysine). Note: Compared to the Sickle cell mutation, the clinical effects are not as significant since the change is from one hydrophilic to another hydrophilic residue versus the change in Sickle cell anemia which involves a hydrophilic residue being replaced by a hydrophobic residue.